How lifestyle factors affect Alzheimer's disease in adults with Down syndrome
Lifestyle and Alzheimer's Disease In Down Syndrome
This study is looking at how things like exercise, sleep, mental activities, and socializing can affect the risk of developing Alzheimer's in adults with Down syndrome, to see if making healthier lifestyle choices can help them stay well longer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10911984 on NIH RePORTER |
What this research studies
This research investigates the impact of four lifestyle factors—physical activity, sleep, cognitive stimulation, and social engagement—on the development of Alzheimer's disease in adults with Down syndrome. Over a period of five years, the study will assess these factors at three different time points to understand their influence on Alzheimer's neuropathology and the transition to clinical symptoms. By focusing on adults with Down syndrome, who are genetically predisposed to Alzheimer's, the research aims to identify how lifestyle choices may alter the course of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with Down syndrome who are 21 years or older.
Not a fit: Patients without Down syndrome or those who are younger than 21 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted lifestyle interventions that may delay or prevent the onset of Alzheimer's disease in individuals with Down syndrome.
How similar studies have performed: Previous research has shown that lifestyle factors can influence Alzheimer's disease progression in non-Down syndrome populations, suggesting potential for success in this novel approach.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Hartley, Sigan L — University of Wisconsin-Madison
- Study coordinator: Hartley, Sigan L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.