How leukemia affects heart metabolism
Official title: Regulation of cardiac metabolism during Leukemia
Funded at Cedars-Sinai Medical Center · NIH-11027592 · Data updated 2026-11-12
This study is looking at how acute myeloid leukemia (AML) affects the heart, especially how certain substances from the cancer can change how the heart works, which might lead to heart problems even after treatment, and it involves checking patients' heart health and metabolism during and after their leukemia journey.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | March 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $549,796 |
| NIH project number | 1R01HL177461-01 |
| Project ID | NIH-11027592 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with acute myeloid leukemia who are undergoing treatment or have recently completed treatment.
✕Less likely to help
Patients with other types of leukemia or those without any form of blood cancer may not benefit from this research.
What this research studies
This research investigates the impact of acute myeloid leukemia (AML) on heart metabolism and function. It focuses on how specific cancer-related metabolites disrupt the normal functioning of heart cells, potentially leading to heart failure even after leukemia treatment. By analyzing genetic mutations associated with AML, the study aims to uncover the mechanisms that cause changes in heart structure and metabolism during and after the disease. Patients may be monitored for metabolic changes and heart function as part of this investigation.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing heart health in patients with leukemia.
How similar studies have gone: Previous research has shown that targeting metabolic pathways in cancer can lead to significant improvements in treatment outcomes, suggesting this approach may also be beneficial.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Karlstaedt, Anja — Cedars-Sinai Medical Center
- Study coordinator: Karlstaedt, Anja
Related research
Other NIH-funded projects on the same topics.
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Investigating a specific type of leukemia in children caused by genetic changes.
This study is looking at how certain proteins linked to leukemia affect kids and teens with high-risk blood cancers, and the researchers hope to find new ways to treat these conditions by learning more about how the disease works.
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Aims to help adults with acute myeloid leukemia by using a special drug approach that makes cancer cells act more like normal blood cells and supports the immune system.
-
Genomics of childhood ALL across global populations
A wide-ranging study looks at how inherited genetics influence the risk of childhood acute lymphoblastic leukemia around the world.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.