How leukemia affects heart metabolism
Regulation of cardiac metabolism during Leukemia
This study is looking at how acute myeloid leukemia (AML) affects the heart, especially how certain substances from the cancer can change how the heart works, which might lead to heart problems even after treatment, and it involves checking patients' heart health and metabolism during and after their leukemia journey.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11027592 on NIH RePORTER |
What this research studies
This research investigates the impact of acute myeloid leukemia (AML) on heart metabolism and function. It focuses on how specific cancer-related metabolites disrupt the normal functioning of heart cells, potentially leading to heart failure even after leukemia treatment. By analyzing genetic mutations associated with AML, the study aims to uncover the mechanisms that cause changes in heart structure and metabolism during and after the disease. Patients may be monitored for metabolic changes and heart function as part of this investigation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with acute myeloid leukemia who are undergoing treatment or have recently completed treatment.
Not a fit: Patients with other types of leukemia or those without any form of blood cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing heart health in patients with leukemia.
How similar studies have performed: Previous research has shown that targeting metabolic pathways in cancer can lead to significant improvements in treatment outcomes, suggesting this approach may also be beneficial.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Karlstaedt, Anja — Cedars-Sinai Medical Center
- Study coordinator: Karlstaedt, Anja
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.