How learning changes brain connections related to smell processing
Learning-mediated plasticity in cortical feedback projections to the olfactory bulb
This study looks at how learning helps our brains recognize different smells better, using mice to see how their brain cells work together when they learn to identify specific odors.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-11002568 on NIH RePORTER |
What this research studies
This research investigates how learning affects the way neurons in the brain process smells. By studying mice as they learn to identify specific odors in complex mixtures, researchers will analyze the activity and connectivity of neurons in the olfactory bulb and the piriform cortex. The goal is to understand how these brain areas work together to improve our ability to distinguish different smells. This could provide insights into the mechanisms of sensory processing and how the brain adapts to new information.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurodegenerative conditions that impact their sensory perception, particularly those related to smell.
Not a fit: Patients with non-neurodegenerative conditions or those without sensory processing issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of neurodegenerative diseases that affect sensory processing.
How similar studies have performed: Other research has shown promising results in understanding sensory processing and learning, making this approach both relevant and potentially impactful.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Zak, Joseph Donald — University of Illinois at Chicago
- Study coordinator: Zak, Joseph Donald
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.