How learning changes brain connections in motor control neurons
Official title: Learning-induced synaptic plasticity in corticospinal output neurons of motor cortex
Funded at University of California, San Diego · NIH-11032108 · Data updated 2026-11-12
This study is looking at how learning new movements changes the way brain cells in the motor cortex connect and work together, helping us understand how we improve our skills over time.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | March 1, 2025 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $73,408 |
| NIH project number | 1F32NS140212-01 |
| Project ID | NIH-11032108 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with amyotrophic lateral sclerosis or those experiencing motor control difficulties.
✕Less likely to help
Patients with non-neurological conditions or those not experiencing motor control issues may not benefit from this research.
What this research studies
This research investigates how learning affects the connections between neurons in the motor cortex, which are crucial for controlling movement. By using advanced imaging techniques and genetically-encoded sensors, the study aims to observe changes in neural activity as individuals learn new motor skills. This approach allows researchers to measure both synaptic and spiking activity in specific neurons that influence muscle control, providing insights into the underlying mechanisms of learning and behavior adaptation.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for conditions like amyotrophic lateral sclerosis by enhancing our understanding of motor neuron function and plasticity.
How similar studies have gone: Previous research has shown promising results in understanding synaptic plasticity and learning mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Li, Jennifer Ying — University of California, San Diego
- Study coordinator: Li, Jennifer Ying
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.