How lead exposure in early life may increase the risk of Alzheimer's disease
Mechanisms of gene-environment interaction in developmental lead exposure leading to Alzheimer's disease phenotypes
This study is looking at how being exposed to lead while growing up might change brain function and increase the risk of developing Alzheimer's disease later on, so we can better understand how environmental factors like lead can affect brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project ID | NIH-10909218 on NIH RePORTER |
What this research studies
This research investigates how exposure to lead during development can affect brain function and potentially lead to Alzheimer's disease later in life. The study focuses on understanding the biological mechanisms, particularly epigenetic changes, that occur due to this exposure and how they interact with genetic factors associated with Alzheimer's. By examining these interactions, the research aims to uncover how lead exposure alters brain signaling pathways, which may contribute to the development of Alzheimer's disease symptoms. Patients may benefit from insights gained about environmental risk factors and their role in Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of developmental lead exposure or those concerned about their risk for Alzheimer's disease.
Not a fit: Patients who have not been exposed to lead or do not have a family history of Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for Alzheimer's disease linked to environmental exposures.
How similar studies have performed: Other research has shown promising results in understanding the impact of environmental factors on neurological diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
West Lafayette, United States
- Purdue University — West Lafayette, United States (Active)
Researchers
- Principal investigator: Freeman, Jennifer L. — Purdue University
- Study coordinator: Freeman, Jennifer L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.