How lead exposure during pregnancy affects gene regulation in mice
Imprinted Gene Regulation by in utero Lead Exposure in Mice
['FUNDING_CAREER'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-11032850
This study looks at how being exposed to lead during pregnancy affects the genes of baby mice, helping us understand the potential risks for human babies when they are developing in the womb.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-11032850 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of lead exposure during pregnancy on the regulation of genes in developing mice. By exposing pregnant mice to levels of lead that are relevant to human populations, the study aims to understand how this exposure alters the genetic imprinting process, which is crucial for normal development. The researchers will analyze changes in DNA methylation and other epigenetic mechanisms that may lead to adverse health outcomes later in life. This work could provide insights into the risks associated with environmental toxins during critical periods of development.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be pregnant individuals exposed to lead or those concerned about environmental toxins affecting their children.
Not a fit: Patients who are not pregnant or who have no history of lead exposure may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of how lead exposure affects child development and inform public health strategies to mitigate these risks.
How similar studies have performed: Previous research has shown that environmental toxins can disrupt gene regulation, suggesting that this study's approach may yield valuable insights.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PERERA, BAMBARENDAGE PINITHI UPEKKA — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: PERERA, BAMBARENDAGE PINITHI UPEKKA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.