How lactate and ketones might reduce heart inflammation after a heart attack
Anti-Inflammatory Roles and Macrophage Metabolism of Lactate and Ketones during Myocardial Infarction
This work looks at whether lactate and ketone molecules can calm immune cells and help hearts heal after a heart attack, especially in people with diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project ID | NIH-11143245 on NIH RePORTER |
What this research studies
Researchers are studying how immune cells called macrophages change their fuel use after a heart attack and whether lactate and ketone bodies push them toward a healing, anti-inflammatory state. Much of the work uses laboratory models of heart attack and metabolic tests to measure how macrophages burn glucose, lactate, or ketones. The team will compare responses in diabetic versus non-diabetic settings to understand why people with diabetes heal worse after heart attacks. Findings are intended to point toward treatments that could improve healing and lower the chance of heart failure.
Who could benefit from this research
Good fit: Adults who have had a recent heart attack, especially those with diabetes, would be the most relevant group for this line of research.
Not a fit: People without a recent heart attack, children, or those with non-ischemic heart conditions are unlikely to get direct benefit from this project.
Why it matters
Potential benefit: If successful, this could point to new ways to reduce damaging inflammation after heart attacks and lower the risk of heart failure, particularly for people with diabetes.
How similar studies have performed: Previous research shows immune cells change metabolism during inflammation and that ketones and lactate can reduce inflammation in some models, but applying these approaches to improve healing after heart attack—especially in diabetes—is comparatively new.
Where this research is happening
Jackson, United States
- University of Mississippi Med Ctr — Jackson, United States (Active)
Researchers
- Principal investigator: Mouton, Alan J — University of Mississippi Med Ctr
- Study coordinator: Mouton, Alan J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.