How lactate and ketones affect inflammation and healing after a heart attack
Official title: Anti-Inflammatory Roles and Macrophage Metabolism of Lactate and Ketones during Myocardial Infarction
Funded at University of Mississippi Med Ctr · NIH-10906221 · Data updated 2026-11-12
This study is looking at how certain substances in the body, like lactate and ketones, can help reduce inflammation and speed up healing after a heart attack, especially for people with diabetes, by understanding how immune cells change their energy use during recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project start | August 11, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $584,122 |
| NIH project number | 5R01HL166737-02 |
| Project ID | NIH-10906221 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who have experienced a myocardial infarction, particularly those with diabetes.
✕Less likely to help
Patients who have not experienced a myocardial infarction or do not have diabetes may not benefit from this research.
What this research studies
This research investigates the role of lactate and ketones in reducing inflammation and promoting healing after a heart attack, particularly in patients with diabetes. It focuses on how macrophages, a type of immune cell, change their metabolism during different phases of recovery from a heart attack. By analyzing these metabolic changes, the research aims to identify new therapeutic targets that could improve healing and reduce heart failure risk in affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance recovery and reduce complications after heart attacks, especially for diabetic patients.
How similar studies have gone: Previous research has shown promising results in targeting macrophage metabolism to improve healing after heart attacks, suggesting this approach could be effective.
Where this research is happening
-
University of Mississippi Med Ctr
Jackson, United States Active
Researchers
- Principal investigator: Mouton, Alan J — University of Mississippi Med Ctr
- Study coordinator: Mouton, Alan J
Related research
Other NIH-funded projects on the same topics.
-
Anti-inflammatory signaling of a key protein in heart attack recovery
A study in people who have had a heart attack is exploring how a macrophage protein called Tristetraprolin may reduce inflammation and help protect heart tissue.
-
Targeting RIPK3 to reduce heart damage after a heart attack
This grant studies a specific cell-death pathway (RIPK3) to protect the heart after a heart attack, with the goal of reducing damage and improving recovery.
-
mRNA lipid nanoparticles to help heart attack patients grow healthier blood vessels
A heart-attack study tests a new treatment that uses messenger RNA delivery with tiny fat bubbles to promote normal blood vessel growth in damaged heart tissue.
-
Targeted nanotherapy to calm inflammation, grow new blood vessels, and prevent scarring after a heart attack
A new treatment approach uses engineered secretions from immune cells delivered early after a heart attack to reduce inflammation, promote blood vessel growth, and limit scarring to protect heart function.
-
Why heart attacks and strokes affect people differently across places and races
This project follows adults across the U.S. to see how lifelong social and neighborhood factors shape heart attacks, heart failure, and recovery, with attention to Black adults and regions with high disease rates.
-
Real-time multi-lead ECG from wearables to help detect heart attacks early
A new AI-based approach uses everyday wearable sensors to turn simple PPG signals into multi-lead ECG data to monitor for heart attacks in real time, even outside the clinic.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.