How lactate and ketones affect inflammation and healing after a heart attack
Anti-Inflammatory Roles and Macrophage Metabolism of Lactate and Ketones during Myocardial Infarction
This study is looking at how certain substances in the body, like lactate and ketones, can help reduce inflammation and speed up healing after a heart attack, especially for people with diabetes, by understanding how immune cells change their energy use during recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Mississippi Med Ctr NIH-funded |
| Lab location | 1 site (Jackson, United States) |
| Project ID | NIH-10906221 on NIH RePORTER |
What this research studies
This research investigates the role of lactate and ketones in reducing inflammation and promoting healing after a heart attack, particularly in patients with diabetes. It focuses on how macrophages, a type of immune cell, change their metabolism during different phases of recovery from a heart attack. By analyzing these metabolic changes, the research aims to identify new therapeutic targets that could improve healing and reduce heart failure risk in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have experienced a myocardial infarction, particularly those with diabetes.
Not a fit: Patients who have not experienced a myocardial infarction or do not have diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance recovery and reduce complications after heart attacks, especially for diabetic patients.
How similar studies have performed: Previous research has shown promising results in targeting macrophage metabolism to improve healing after heart attacks, suggesting this approach could be effective.
Where this research is happening
Jackson, United States
- University of Mississippi Med Ctr — Jackson, United States (Active)
Researchers
- Principal investigator: Mouton, Alan J — University of Mississippi Med Ctr
- Study coordinator: Mouton, Alan J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.