How KSHV affects the immune system and cancer development
Modulation of Innate Immunity by KSHV
This study is looking at how a virus called KSHV affects the immune system and can lead to cancer, especially in people with weakened immune systems like those with HIV, to find ways to prevent or treat cancers linked to this virus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10421081 on NIH RePORTER |
What this research studies
This research investigates the role of the Kaposi's Sarcoma-associated Herpesvirus (KSHV) in modulating the immune system and its connection to cancer development. The study focuses on understanding how KSHV can remain dormant in the body and how it can lead to cancers, particularly in individuals with weakened immune systems, such as those with HIV. By examining the interactions between KSHV and the immune response, the research aims to uncover mechanisms that could help prevent KSHV-related malignancies. Patients may benefit from insights that could lead to new prevention or treatment strategies for KSHV-associated cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with KSHV infection, especially those with compromised immune systems or a history of KSHV-associated cancers.
Not a fit: Patients who do not have KSHV infection or related malignancies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for cancers associated with KSHV.
How similar studies have performed: Previous research has shown promising results in understanding the immune response to KSHV, indicating that this area of study has potential for significant advancements.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Damania, Blossom a — Univ of North Carolina Chapel Hill
- Study coordinator: Damania, Blossom a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.