How kidney disease affects immune responses to vaccines
Impaired B Cell and Vaccine Responses with Advance Renal Disease
['FUNDING_OTHER'] · VA EASTERN COLORADO HEALTH CARE SYSTEM · NIH-10919755
This study is looking at how advanced kidney disease affects the immune system's ability to respond to pneumonia vaccines, especially focusing on a type of immune cell called B cells, to help understand why people with chronic kidney disease or end-stage renal disease are more likely to get infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VA EASTERN COLORADO HEALTH CARE SYSTEM (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-10919755 on ClinicalTrials.gov |
What this research studies
This research investigates how advanced renal disease impacts the immune system's ability to respond to pneumococcal vaccines, particularly focusing on B cells and their role in antibody production. It aims to understand the mechanisms behind reduced antibody responses in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). By examining the maturation of B cells and the processes involved in antibody formation, the study seeks to identify why these patients have a higher risk of infections like pneumonia. The research will involve analyzing both mucosal and systemic immune responses to better understand the challenges faced by these patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have chronic kidney disease or end-stage renal disease.
Not a fit: Patients without kidney disease or those who are not adults may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccination strategies and better protection against infections for patients with kidney disease.
How similar studies have performed: While there is limited research specifically on CKD and vaccine responses, similar studies have shown that understanding immune responses can lead to improved vaccination outcomes in other populations.
Where this research is happening
Aurora, UNITED STATES
- VA EASTERN COLORADO HEALTH CARE SYSTEM — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JANI, ALKESH HARIHAR — VA EASTERN COLORADO HEALTH CARE SYSTEM
- Study coordinator: JANI, ALKESH HARIHAR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.