How kidney cell mitochondria and angiotensin affect high blood pressure
Novel Roles and Mechanisms of Proximal Tubule Mitochondrial Angiotensin II and Sirtuin 3 in Hypertension
['FUNDING_R01'] · TULANE UNIVERSITY OF LOUISIANA · NIH-11385301
This project looks at how angiotensin and a mitochondrial protein called SIRT3 in kidney cells influence mitochondria and contribute to high blood pressure.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TULANE UNIVERSITY OF LOUISIANA (nih funded) |
| Locations | 1 site (NEW ORLEANS, UNITED STATES) |
| Trial ID | NIH-11385301 on ClinicalTrials.gov |
What this research studies
Researchers will use laboratory experiments, including cell and animal models, to study how angiotensin signals inside proximal tubule kidney cells change mitochondrial function. They will examine two opposing mitochondrial angiotensin pathways and how SIRT3 helps control oxidative stress and energy use in these cells. The team will measure mitochondrial enzymes, reactive oxygen levels, and blood pressure-related effects to map the chain of events that leads to hypertension and kidney injury. The goal is to find molecular steps that could be targeted to protect kidneys and lower blood pressure.
Who could benefit from this research
Good fit: Adults with high blood pressure, particularly those with signs of kidney injury or who take antihypertensive medications, would be the most relevant patient group for this research.
Not a fit: People without hypertension, children under 21, or patients whose kidney disease has unrelated causes are less likely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could point to new ways to protect kidney mitochondria and lower blood pressure, leading to better treatments for hypertension-related kidney damage.
How similar studies have performed: Prior laboratory studies, including the investigators' previous work, have supported roles for mitochondrial angiotensin signaling and SIRT3 in animal and cell models, but translating these findings into patient therapies is still early.
Where this research is happening
NEW ORLEANS, UNITED STATES
- TULANE UNIVERSITY OF LOUISIANA — NEW ORLEANS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHUO, JIA LONG — TULANE UNIVERSITY OF LOUISIANA
- Study coordinator: ZHUO, JIA LONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.