How kidney blood flow is affected by urinary tract blockage in newborns
Official title: Vascular ion channels and microcirculation in neonatal urinary tract obstruction
Funded at University of Missouri-Columbia · NIH-10954562 · Data updated 2026-11-12
This study is looking at how blockages in the urinary tract can harm the kidneys of newborns, using baby pigs and special baby rats to learn more about how blood flow in the kidneys is affected, which could help improve care for infants with these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | October 19, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $491,984 |
| NIH project number | 7R01DK120595-05 |
| Project ID | NIH-10954562 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newborns experiencing urinary tract obstructions or related kidney issues.
✕Less likely to help
Patients who are older children or adults, or those without urinary tract obstructions, may not benefit from this research.
What this research studies
This research investigates how urinary tract obstruction can lead to kidney injury in newborns, focusing on the vascular mechanisms that affect blood flow in the kidneys. By using newborn pigs and a special strain of neonatal rats, the study aims to understand how certain molecules influence kidney blood vessel function during and after an obstruction. The researchers will explore how these mechanisms contribute to kidney damage and impaired blood flow regulation, which are critical for the health of infants with urinary tract issues.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for preventing kidney damage in infants with urinary tract obstructions.
How similar studies have gone: While the specific approach of this research is novel, previous studies have shown that understanding vascular mechanisms can lead to significant advancements in treating kidney-related conditions.
Where this research is happening
-
University of Missouri-Columbia
Columbia, United States Active
Researchers
- Principal investigator: Adebiyi, Adebowale — University of Missouri-Columbia
- Study coordinator: Adebiyi, Adebowale
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.