How key brain proteins shape nerve-cell connections
Analysis of Synaptic Protein Dynamics
['FUNDING_R01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-11366073
Researchers are looking at how certain proteins that control nerve-cell communication work to help people with neurological conditions like autism and epilepsy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11366073 on ClinicalTrials.gov |
What this research studies
This project studies proteins called Munc13 and Munc18 that help nerve cells release signals at synapses. The team combines mouse experiments, high-resolution imaging, genetics, behavioral tests, and protein/lipid biochemistry to see how mutations change synapse function. By linking molecular changes to brain activity and behavior, they aim to build a clearer picture of how these protein defects contribute to disease. The work is mainly lab-based and focused on mechanisms that underlie conditions such as autism and epileptic encephalopathies.
Who could benefit from this research
Good fit: This grant does not directly enroll patients, but people with genetic forms of autism or epilepsy (for example mutations in UNC13A or STXBP1) could be candidates for future related studies.
Not a fit: People seeking immediate treatments or symptom relief are unlikely to benefit directly from this basic laboratory research.
Why it matters
Potential benefit: If successful, the work could reveal how specific protein defects lead to autism or epilepsy and point to targets for future therapies.
How similar studies have performed: Previous biochemical and animal-model studies have clarified synapse mechanisms before, but this integrated in vivo/in vitro focus on Munc13 and Munc18 is relatively novel.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DITTMAN, JEREMY SAMUEL — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: DITTMAN, JEREMY SAMUEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autistic Disorder