How ketogenic diets affect gut bacteria and metabolism
Host-microbiome interactions shape the metabolic effects of ketogenic diets
This study is looking at how a ketogenic diet, which is low in carbs and high in fats, affects the bacteria in your gut and your overall health, especially for people dealing with obesity and related conditions, to find better ways to help manage these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10788377 on NIH RePORTER |
What this research studies
This research investigates how ketogenic diets, which are very low in carbohydrates and high in fats, influence the gut microbiome and metabolic health. It aims to understand the interactions between the host's metabolism and gut bacteria, particularly how changes in diet can affect immune responses and metabolic conditions. By examining these relationships, the study seeks to uncover mechanisms that could lead to improved treatments for obesity and related metabolic diseases. The research employs advanced techniques to manipulate both the host's genetics and the gut microbiome to explore these interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are struggling with obesity or related metabolic conditions.
Not a fit: Patients who are not overweight or do not have metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective dietary strategies for managing obesity and improving metabolic health.
How similar studies have performed: Previous research has shown promising results in understanding the impact of diets on gut microbiota, making this approach both innovative and grounded in existing scientific literature.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Turnbaugh, Peter James — University of California, San Francisco
- Study coordinator: Turnbaugh, Peter James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.