How keratin proteins influence skin cell behavior and cancer development
Keratin and filament cell-cell junction cooperation in developmental and tumorigenic fate decisions
['FUNDING_OTHER'] · UNIVERSITY OF MICHIGAN AT ANN ARBOR · NIH-10949070
This study is looking at a special protein in your skin called keratin 14 to see how it affects skin cells and their behavior, which could help us understand skin health and cancer better, especially in situations where the skin is under stress.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MICHIGAN AT ANN ARBOR (nih funded) |
| Locations | 1 site (ANN ARBOR, UNITED STATES) |
| Trial ID | NIH-10949070 on ClinicalTrials.gov |
What this research studies
This research investigates the role of keratin proteins, specifically keratin 14, in skin cell behavior and their potential impact on cancer development. By studying how these proteins interact and change in response to various conditions, the research aims to understand their influence on cell communication and growth. The approach includes creating genetically modified mouse models to observe the effects of specific keratin mutations on skin health and cancer progression. This could provide insights into how skin cells maintain their structure and function, especially under stress or disease conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of skin conditions or those at high risk for skin cancer.
Not a fit: Patients with non-skin-related cancers or those without any skin health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating skin cancers by targeting the mechanisms that regulate skin cell behavior.
How similar studies have performed: Previous research has shown promising results in understanding the role of keratins in skin biology and cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
ANN ARBOR, UNITED STATES
- UNIVERSITY OF MICHIGAN AT ANN ARBOR — ANN ARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: REDMOND, CATHERINE JULIA — UNIVERSITY OF MICHIGAN AT ANN ARBOR
- Study coordinator: REDMOND, CATHERINE JULIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.