How 'jumping genes' shape genomes and body function
Genomic and Physiological Impact of Transposable Elements.
The team is looking at how mobile 'jumping genes' change DNA and influence development in humans and zebrafish.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-11311304 on NIH RePORTER |
What this research studies
This project studies transposable elements—bits of DNA that can move around—and how recently active ones affect gene control during early development. Scientists will combine genomic sequencing, computational analysis, and lab experiments using zebrafish embryos alongside human cells or tissue samples to trace effects on gene expression and protein function. They will compare ancient, inactive elements with young, mobile ones to identify which create new regulatory elements or proteins. Functional lab tests will link these DNA changes to cellular and developmental outcomes.
Who could benefit from this research
Good fit: Most direct involvement would come from people able to donate biological samples or from patients with unexplained developmental or genetic conditions.
Not a fit: People with health issues unrelated to genetics or development are unlikely to receive direct benefits from this basic research.
Why it matters
Potential benefit: If successful, this work could clarify causes of developmental or genetic disorders and point to new diagnostic markers or therapeutic targets.
How similar studies have performed: Previous studies have shown ancient transposable elements can create new gene regulators and proteins, but probing the impact of recently active 'young' elements in development is newer and less established.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Feschotte, Cedric — Cornell University
- Study coordinator: Feschotte, Cedric
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.