How isocyanates at work cause asthma
Deciphering Occupational Asthma Pathogenesis Caused by Isocyanate
How workplace chemicals called diisocyanates cause asthma in workers exposed to them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11163187 on NIH RePORTER |
What this research studies
This research looks at why some workers who breathe in chemicals called diisocyanates develop severe asthma while others do not. Scientists use a new mouse method that delivers these chemicals deep into the lungs to mirror workplace exposures and study immune reactions. They compare animals that were sensitized to the chemical with those that were not to find patterns and potential exposure markers. The findings are intended to point toward tests or prevention strategies that could later be tried in people who work with these chemicals.
Who could benefit from this research
Good fit: Ideal participants would be current or former workers with known diisocyanate exposure or people diagnosed with occupational asthma linked to these chemicals.
Not a fit: People whose asthma is purely environmental and unrelated to workplace chemical exposures are unlikely to benefit directly from this work.
Why it matters
Potential benefit: Could identify biomarkers and immune patterns that enable earlier detection, better workplace screening, and new ways to prevent or treat diisocyanate-related occupational asthma.
How similar studies have performed: Previous work, including the team's own mouse model, has produced new immune insights but translation to human screening tests and treatments remains limited.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Wisnewski, Adam — Yale University
- Study coordinator: Wisnewski, Adam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.