How iron regulation affects blood cell production and anemia
Official title: Cell Cycle Regulation of IRP2 Phosphorylation During Hematopoiesis
Funded at University of Utah · NIH-10877922 · Data updated 2026-11-12
This study is looking at how a protein called Irp2 helps make blood cells and how changes in this protein might affect anemia, using specially modified mice to learn more about its role in managing iron in the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $517,895 |
| NIH project number | 5R01HL168492-02 |
| Project ID | NIH-10877922 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing anemia or related blood disorders.
✕Less likely to help
Patients with iron overload conditions or those not affected by anemia may not benefit from this research.
What this research studies
This research investigates the role of iron-regulatory protein 2 (Irp2) in the production of blood cells and its impact on anemia. It focuses on how Irp2 is regulated during the cell cycle, particularly through phosphorylation, and how this affects the translation of important mRNAs involved in iron metabolism. By studying genetically modified mice, the research aims to understand the consequences of disrupted Irp2 function on blood cell development and overall iron regulation in the body.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for anemia and other blood disorders.
How similar studies have gone: Other research has shown promising results in understanding iron metabolism and its effects on blood disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Leibold, Elizabeth Ann — University of Utah
- Study coordinator: Leibold, Elizabeth Ann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.