How ion transporters and the cytoskeleton affect breast cancer cell movement and spread
The interplay of ion transporters and cytoskeleton in breast cancer migration and metastasis
This study is looking at how certain cells in triple negative breast cancer move around and spread in the body, hoping to find new ways to help treat patients who currently have limited options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11045673 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind breast cancer cell migration and metastasis, focusing on the interaction between ion transporters and the cytoskeleton. By utilizing advanced bioengineering techniques and imaging tools, the study aims to understand how these components work together to facilitate cancer cell movement. The research will specifically examine triple negative breast cancer (TNBC) cells, which currently lack effective targeted therapies, using both cell lines and patient-derived models. The goal is to uncover new insights that could lead to improved treatment strategies for breast cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with triple negative breast cancer (TNBC).
Not a fit: Patients with non-breast cancers or those with breast cancer types other than triple negative may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies that effectively target and inhibit breast cancer metastasis.
How similar studies have performed: Other research has shown promising results in understanding cancer cell migration through similar approaches, indicating potential for success in this area.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Konstantopoulos, Konstantinos — Johns Hopkins University
- Study coordinator: Konstantopoulos, Konstantinos
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.