How ion flow affects immune cells in lung injury and healing
Ion Flux Regulation of Macrophage Plasticity in Lung Injury and Repair
This study is looking at how certain immune cells in the lungs react to signals that can either make lung inflammation worse or help it heal, with the goal of finding new ways to treat lung injuries.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-10895343 on NIH RePORTER |
What this research studies
This research investigates how macrophages, a type of immune cell in the lungs, respond to signals that can either promote or heal lung inflammation. The study focuses on the role of specific receptors and ion channels that regulate calcium and potassium levels in these cells, which are crucial for determining their function. By understanding these mechanisms, the research aims to identify how macrophages can be directed to either exacerbate or resolve lung injuries, potentially leading to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from inflammatory lung conditions, such as asthma or chronic obstructive pulmonary disease (COPD).
Not a fit: Patients with non-inflammatory lung conditions or those without significant lung injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the healing process in lung injuries by manipulating immune cell behavior.
How similar studies have performed: Previous research has shown promising results in manipulating immune cell behavior through ion channel regulation, indicating potential for success in this approach.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Kim, Kiwook — University of Illinois at Chicago
- Study coordinator: Kim, Kiwook
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.