How ion channels control blood flow in small blood vessels
Control of microvascular function by ion channels
['FUNDING_R01'] · UNIVERSITY OF MISSOURI-COLUMBIA · NIH-10939562
This study looks at how a special channel in nerve cells, called TRPM8, affects blood flow in tiny blood vessels, which is important for people with heart and kidney issues, to help us understand how it controls the release of signals that keep our organs well-supplied with blood.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MISSOURI-COLUMBIA (nih funded) |
| Locations | 1 site (COLUMBIA, UNITED STATES) |
| Trial ID | NIH-10939562 on ClinicalTrials.gov |
What this research studies
This research investigates how specific ion channels in nerve cells influence blood flow in small blood vessels, particularly in the context of cardiovascular and kidney diseases. By examining the role of the TRPM8 ion channel, which is sensitive to cold, the study aims to understand how it affects the release of neurotransmitters that regulate vascular tone and organ perfusion. The research employs a combination of laboratory experiments and physiological assessments to explore these mechanisms and their implications for microcirculation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from cardiovascular or kidney diseases who may experience issues with blood flow and organ perfusion.
Not a fit: Patients without cardiovascular or kidney diseases are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for improving blood flow and organ function in patients with cardiovascular and kidney diseases.
How similar studies have performed: While the specific role of TRPM8 in microvascular function is still being explored, there is a growing body of literature suggesting that targeting ion channels can lead to significant advancements in understanding vascular health.
Where this research is happening
COLUMBIA, UNITED STATES
- UNIVERSITY OF MISSOURI-COLUMBIA — COLUMBIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ADEBIYI, ADEBOWALE — UNIVERSITY OF MISSOURI-COLUMBIA
- Study coordinator: ADEBIYI, ADEBOWALE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.