How intestinal worms affect viral infections in the gut
An Intestinal Helminth Promotes Enteric Viral Infection Independent of Type 2 Immunity
This study looks at how infections from certain worms in the intestines might affect the body's ability to fight off viruses, especially adenoviruses, and aims to help us understand how these infections could impact our immune system and overall health.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11092811 on NIH RePORTER |
What this research studies
This research investigates the impact of intestinal helminth infections on the body's ability to fight off viral infections, particularly focusing on adenoviruses. It explores how these parasitic worms, while generally non-harmful, may weaken the immune response against certain viruses by altering the body's inflammatory responses. Using a mouse model, the study examines the interactions between helminths and viral infections to understand the underlying mechanisms that could affect human health. Patients may benefit from insights gained about how these infections influence immune responses and viral replication.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with helminth infections who are also experiencing viral infections, particularly those related to the gastrointestinal tract.
Not a fit: Patients without helminth infections or those not affected by viral infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing viral infections in patients with helminth infections.
How similar studies have performed: Previous studies have shown that helminth infections can influence immune responses, suggesting that this research builds on established findings in the field.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Von Moltke, Jakob H. — University of Washington
- Study coordinator: Von Moltke, Jakob H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.