How intestinal parasites affect immune responses to food
Role of Intestinal Parasites on Regulating Immune Responses to Gut Antigens
This study is looking at how certain intestinal parasites might help our immune system get along better with the foods we eat, which could lead to new ways to prevent allergies and autoimmune diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11088895 on NIH RePORTER |
What this research studies
This research investigates the role of intestinal parasites in shaping immune responses, particularly how they influence the body's tolerance to food antigens. By studying two different parasites that provoke distinct immune responses, the research aims to uncover mechanisms that may help prevent allergic and autoimmune diseases. The approach involves analyzing T cell responses in mice to understand how these parasites can both trigger immune reactions and promote tolerance to harmless food substances. This could provide insights into the hygiene hypothesis, which links sanitation practices to rising rates of allergies and autoimmune conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years living in regions where gastrointestinal parasitic infections are prevalent.
Not a fit: Patients who do not have gastrointestinal parasitic infections or are outside the targeted age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing allergic and autoimmune diseases in children.
How similar studies have performed: Previous research has shown that understanding the immune response to parasites can lead to breakthroughs in managing allergic and autoimmune diseases, suggesting this approach has potential for success.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Edelson, Brian Todd — Washington University
- Study coordinator: Edelson, Brian Todd
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.