How intestinal immune responses affect Coxsackievirus B3 infections
Official title: Intestinal NOD2 and the microbiota enhance Coxsackievirus B3 pathogenesis
Funded at University of Colorado Denver · NIH-11037692 · Data updated 2026-11-12
This study is looking at how a specific part of your immune system, called NOD2, works in your intestines and how it interacts with the bacteria in your gut to see if it makes viral infections, like Coxsackievirus B3, worse, with the hope of finding new ways to help people feel better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | December 5, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $226,641 |
| NIH project number | 1R21AI188344-01 |
| Project ID | NIH-11037692 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of viral infections, particularly those affecting the gastrointestinal tract, and those with conditions related to intestinal immunity.
✕Less likely to help
Patients with non-viral gastrointestinal issues or those without any history of viral infections may not benefit from this research.
What this research studies
This research investigates the role of a specific immune receptor, NOD2, in the intestines and how it interacts with the microbiota to influence the severity of infections caused by Coxsackievirus B3. The study aims to understand the mechanisms by which NOD2 can exacerbate viral infections, particularly in the context of intestinal health. By examining the immune responses triggered by this virus, the research seeks to uncover potential therapeutic targets for improving patient outcomes. Patients may benefit from insights into how their gut health and immune responses can affect viral infections.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating severe viral infections in patients with compromised intestinal immunity.
How similar studies have gone: Other research has shown promising results in understanding the role of immune receptors in viral infections, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Keestra-Gounder, Arina Marijke — University of Colorado Denver
- Study coordinator: Keestra-Gounder, Arina Marijke
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.