How intestinal fungi affect wound healing in Crohn's disease
Official title: Innate immune responses to tissue infection by intestinal fungi inhibit wound repair
Funded at Cleveland Clinic Lerner Com-Cwru · NIH-10986134 · Data updated 2026-11-12
This study is looking at how a type of yeast called Debaryomyces hansenii might slow down healing in the intestines of people with Crohn's disease, and it hopes to find new ways to help improve healing for those affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | November 14, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $771,486 |
| NIH project number | 5R01AI168411-02 |
| Project ID | NIH-10986134 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Crohn's disease who experience non-healing intestinal wounds.
✕Less likely to help
Patients without Crohn's disease or those who do not have issues with intestinal wound healing may not benefit from this research.
What this research studies
This research investigates the role of a specific yeast, Debaryomyces hansenii, in hindering the healing of intestinal wounds in patients with Crohn's disease. By examining how this fungus interacts with the immune system, the study aims to uncover mechanisms that lead to poor wound repair. The researchers will use animal models to simulate the effects of this yeast on intestinal healing, focusing on immune responses and the production of specific signaling molecules. The findings could provide insights into new treatment strategies for improving wound healing in affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that enhance wound healing in patients with Crohn's disease.
How similar studies have gone: Previous research has shown that alterations in the gut microbiome can significantly impact disease outcomes, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Cleveland Clinic Lerner Com-Cwru
Cleveland, United States Active
Researchers
- Principal investigator: Stappenbeck, Thaddeus S — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Stappenbeck, Thaddeus S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.