How internal states affect decision-making in the brain
State-dependent Decision-making in Brainwide Neural Circuits
This study looks at how changes inside a mouse, like their mood or energy levels, affect the choices they make, helping us understand more about how brains work when making decisions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10984179 on NIH RePORTER |
What this research studies
This research investigates how an animal's internal state influences its decision-making processes, particularly in mice. By examining various internal state changes, such as engagement in tasks and learning over time, the study aims to uncover the neural mechanisms behind these decisions. The research employs advanced techniques, including simultaneous recordings from multiple brain regions and computational modeling, to analyze how these internal states interact with external stimuli. The findings could provide insights into the fundamental processes of decision-making in the brain.
Who could benefit from this research
Good fit: Ideal candidates for this research would be individuals interested in the neurological basis of decision-making and those affected by cognitive disorders.
Not a fit: Patients with conditions unrelated to decision-making processes or those not interested in neurological research may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of decision-making processes, potentially leading to new treatments for disorders that affect cognition and behavior.
How similar studies have performed: While the specific approach of this research is ambitious, similar studies have shown success in understanding neural mechanisms in decision-making.
Where this research is happening
New York, United States
- Columbia Univ New York Morningside — New York, United States (Active)
Researchers
- Principal investigator: Paninski, Liam M — Columbia Univ New York Morningside
- Study coordinator: Paninski, Liam M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.