How internal states affect communication in brain circuits
Influence of internal state on communication in distributed neuronal circuits
This study is looking at how different feelings and levels of focus affect how brain cells talk to each other, which could help us understand and improve treatments for conditions like autism.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10906291 on NIH RePORTER |
What this research studies
This research investigates how changes in internal states, such as engagement and vigilance, influence communication within neuronal circuits in the brain. By using advanced techniques like functional MRI and standardized decision-making tasks in mice, the team aims to uncover the neural mechanisms that underlie flexible behavior and the etiology of disorders like autism. The study focuses on understanding how information flows between different brain regions and how this affects behavior. Insights gained could lead to better understanding and treatment of conditions that involve altered internal states.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder (ASD) or related conditions.
Not a fit: Patients without autism or those with unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of autism and lead to improved interventions for individuals with the disorder.
How similar studies have performed: Previous research has shown promising results in understanding brain communication and behavior, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia Univ New York Morningside — New York, United States (Active)
Researchers
- Principal investigator: Steinmetz, Nicholas — Columbia Univ New York Morningside
- Study coordinator: Steinmetz, Nicholas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.