How interleukin-1alpha affects immune responses and cell functions
Official title: Regulation of cellular functions and innate immunity by interleukin-1alpha
Funded at Cedars-Sinai Medical Center · NIH-10979163 · Data updated 2026-11-12
This study is looking at how a protein called IL-1α helps control the immune system and inflammation, especially how it gets released from dying cells and attracts immune cells to areas that need healing, which could lead to new treatments for inflammation-related conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | November 3, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $590,904 |
| NIH project number | 5R01AI175101-02 |
| Project ID | NIH-10979163 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing inflammatory diseases or conditions that involve immune system dysregulation.
✕Less likely to help
Patients with non-inflammatory conditions or those not affected by immune system issues may not benefit from this research.
What this research studies
This research investigates the role of interleukin-1alpha (IL-1α) in regulating immune responses and cellular functions, particularly in the context of inflammation. The study aims to understand how IL-1α is released from dying cells and its effects on recruiting immune cells, such as neutrophils, to sites of inflammation. By using crystalline silica to simulate a sterile inflammatory response, researchers will explore the mechanisms behind IL-1α's actions and its interactions with specific phospholipids. This research could provide insights into the biological functions of IL-1α and its potential therapeutic implications.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance immune responses and improve outcomes for patients with inflammatory conditions.
How similar studies have gone: Previous research has shown promising results in understanding the role of cytokines like IL-1α in inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Sutterwala, Fayyaz S. — Cedars-Sinai Medical Center
- Study coordinator: Sutterwala, Fayyaz S.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.