How interferon affects the replication of certain viruses in primates
Effects of Interferon on primate lentiviruses
This study is looking at how certain proteins in our body can help fight off viruses like HIV-1, and it's for anyone interested in understanding how we might develop better treatments for viral infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10886680 on NIH RePORTER |
What this research studies
This research investigates the role of type I interferon and antiviral proteins in limiting the replication of primate lentiviruses, such as HIV-1. By using advanced techniques like CRISPR screens, the study aims to identify specific genes that inhibit viral entry and understand how these genes interact with different strains of the virus. The research also involves creating chimeric viruses that mimic human HIV-1 strains to study their effects in non-human primate models. This approach could lead to new insights into how to combat viral infections in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV or those at high risk of HIV infection.
Not a fit: Patients who are not infected with HIV or do not have a risk of HIV exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new antiviral strategies that improve treatment options for patients with HIV/AIDS.
How similar studies have performed: Previous research has shown promise in using interferon and antiviral proteins to limit viral replication, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Hatziioannou, Theodora — Rockefeller University
- Study coordinator: Hatziioannou, Theodora
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.