How interactions between leukemia cells and their environment affect leukemia development
Crosstalk between leukemic blasts and the BM microenvironment contribute to leukemic transformation
This study is looking at how the environment around leukemia cells affects the disease and its treatment, focusing on a protein called EGFL7 that might help leukemia grow, with the goal of finding new ways to help people with acute myeloid leukemia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11051266 on NIH RePORTER |
What this research studies
This research investigates the role of the bone marrow microenvironment in the progression of acute myeloid leukemia (AML). It focuses on understanding how genetic changes in leukemia cells interact with their surrounding environment, which may contribute to the disease's severity and resistance to treatment. The study specifically examines a protein called EGFL7, which is found at high levels in AML patients and may promote the growth of leukemia cells. By exploring these interactions, the research aims to identify new therapeutic targets for AML treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with acute myeloid leukemia, particularly those with poor prognosis.
Not a fit: Patients with other types of leukemia or those who do not have acute myeloid leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with acute myeloid leukemia.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in leukemia, suggesting that this approach may be effective.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Dorrance, Adrienne M. — University of Utah
- Study coordinator: Dorrance, Adrienne M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.