How interactions between DNA elements affect human development and health
Transposable Element Interaction and Its Impact on Human Development and Health
This study is looking at how certain parts of our DNA, often thought of as useless, actually help control how our genes work and can affect our health and development, especially in relation to genetic diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10919184 on NIH RePORTER |
What this research studies
This research investigates the role of transposable elements (TEs), often considered 'junk' DNA, in regulating gene function and their impact on human development and health. By focusing on the interactions between these elements, particularly Alu retrotransposons, the study aims to uncover how they influence pre-mRNA splicing and contribute to genetic diseases. The research employs a novel framework to analyze these interactions, using specific gene models to demonstrate their significance in both evolution and disease etiology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions that may be influenced by transposable element interactions.
Not a fit: Patients with conditions unrelated to genetic factors or transposable element interactions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of genetic diseases and potential new therapeutic approaches.
How similar studies have performed: While the role of transposable elements has been explored, this specific approach to studying their interactions is relatively novel and has not been extensively tested.
Where this research is happening
Cambridge, United States
- Broad Institute, INC. — Cambridge, United States (Active)
Researchers
- Principal investigator: Xia, Bo — Broad Institute, INC.
- Study coordinator: Xia, Bo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.