How integrins affect lung development
Integrins in the Developing Lung
['FUNDING_R01'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-11088199
This study is looking at how certain proteins called integrins help lung cells stick together and grow properly, which could help us understand lung development and diseases better, and it's for anyone interested in how our lungs form and function.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-11088199 on ClinicalTrials.gov |
What this research studies
This research investigates the role of integrins, which are proteins that help cells attach to the extracellular matrix, in the development of the lungs. By studying both human and mouse models, the researchers aim to understand how these proteins influence the behavior of lung epithelial cells during organ development. The study involves creating specific deletions of integrins in lung epithelial cells to observe the resulting effects on lung structure and function. This approach could reveal critical insights into the mechanisms behind developmental lung diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with known genetic mutations affecting lung development or those diagnosed with developmental lung diseases.
Not a fit: Patients with fully developed lungs and no history of developmental lung issues are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for developmental lung diseases and improve outcomes for affected patients.
How similar studies have performed: Previous research has shown that targeting integrins can lead to significant advancements in understanding lung development, indicating a promising avenue for this investigation.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PLOSA, ERIN J — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: PLOSA, ERIN J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.