How insulin signaling in the liver affects glucose and fat metabolism
Anatomical Regulation of Glucose and Lipid Metabolism by Insulin Signaling in Hepatocytes
This study is looking at how different parts of the liver help control sugar and fat levels in the body, which is important for people with diabetes and obesity, to find better ways to treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11092221 on NIH RePORTER |
What this research studies
This research investigates how insulin signaling in different regions of the liver influences the body's ability to manage glucose and fat levels. By using advanced techniques like single-cell transcriptomics and specific mouse models, the study aims to understand the unique roles of various liver cells in regulating metabolism during fasting and after meals. This could lead to new insights into how liver function is affected in conditions like diabetes and obesity, ultimately aiming to improve treatment strategies for these diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with adult-onset diabetes or those at risk of developing metabolic disorders.
Not a fit: Patients with metabolic conditions unrelated to insulin signaling or those with acute liver diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for diabetes and obesity by targeting specific liver functions.
How similar studies have performed: Previous research has shown promising results in understanding liver metabolism, but this approach focusing on anatomical differences in insulin signaling is relatively novel.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Tao, Rongya — Boston Children's Hospital
- Study coordinator: Tao, Rongya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.