How insulin receptors behave in health and disease
Official title: Insulin receptor condensates in health and disease
Funded at Massachusetts General Hospital · NIH-11055107 · Data updated 2026-11-12
This study is looking at how certain tiny structures in our cells that help manage insulin can go wrong and lead to insulin resistance, which is important for people dealing with type 2 diabetes and obesity, with the hope of finding new ways to help manage these conditions.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | March 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $172,140 |
| NIH project number | 1K08DK138287-01A1 |
| Project ID | NIH-11055107 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with insulin resistance, type 2 diabetes, or obesity.
✕Less likely to help
Patients without insulin resistance or related metabolic disorders may not benefit from this research.
What this research studies
This research investigates the role of insulin receptor condensates in the development of insulin resistance, which is linked to conditions like type 2 diabetes and obesity. The study aims to understand how these condensates form in healthy cells and how they become dysfunctional in insulin-resistant states. By examining the physical and chemical properties of these condensates, the research seeks to uncover new mechanisms that contribute to insulin resistance. Patients may benefit from insights that could lead to novel therapeutic strategies for managing diabetes and related metabolic disorders.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for insulin resistance and related diseases, improving patient outcomes.
How similar studies have gone: Other research has shown promising results in understanding cellular condensates, indicating potential for success in this area.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Platt, Jesse Michael — Massachusetts General Hospital
- Study coordinator: Platt, Jesse Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.