How insulin and exercise affect blood vessel function in people with type 2 diabetes
Official title: Extracellular Vesicles, Insulin Action and Exercise on Vascular Function in Type 2 Diabetes
Funded at University of Virginia · NIH-11079560 · Data updated 2026-11-12
This study is looking at how tiny particles in the blood, called extracellular vesicles, affect how insulin works and how exercise impacts blood vessel health in people with type 2 diabetes, to help find better ways to improve their vascular health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | April 25, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $618,972 |
| NIH project number | 5R01DK133598-02 |
| Project ID | NIH-11079560 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with type 2 diabetes, particularly those experiencing issues related to vascular function.
✕Less likely to help
Patients without type 2 diabetes or those with other unrelated vascular conditions may not benefit from this research.
What this research studies
This research investigates the role of extracellular vesicles (EVs) in the relationship between insulin action, exercise, and vascular function in individuals with type 2 diabetes (T2D). By examining how insulin influences the uptake and activity of EVs, the study aims to uncover mechanisms behind vascular dysfunction associated with obesity and T2D. The research will compare the effects of EVs from healthy individuals and those with obesity to understand differences in blood vessel responsiveness. This could lead to new insights into how to improve vascular health in patients with T2D.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies to improve vascular function and overall health in patients with type 2 diabetes.
How similar studies have gone: Previous research has shown promising results in understanding the role of extracellular vesicles in metabolic conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Erdbruegger, Uta — University of Virginia
- Study coordinator: Erdbruegger, Uta
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.