How insulin affects glucose transport in fat cells
Insulin control of GLUT4 traffic to the plasma membrane of adipocytes
['FUNDING_R01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-10655330
This study is looking at how insulin helps move a protein called GLUT4 to the surface of fat cells, which is important for getting sugar into those cells, and it aims to understand how this process works better, especially when insulin levels change, to help find new ways to treat insulin resistance and type 2 diabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10655330 on ClinicalTrials.gov |
What this research studies
This research investigates how insulin regulates the movement of the GLUT4 glucose transporter to the surface of fat cells, which is crucial for glucose uptake. It focuses on understanding the mechanisms that control GLUT4 trafficking between the cell interior and the plasma membrane, particularly during different insulin levels. By studying this process, the research aims to uncover insights into insulin resistance and its link to type 2 diabetes, potentially leading to new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with insulin resistance or type 2 diabetes who are seeking better management options for their condition.
Not a fit: Patients with type 1 diabetes or those without any form of insulin resistance may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for insulin resistance and type 2 diabetes, enhancing glucose control in affected patients.
How similar studies have performed: Previous research has shown promising results in understanding GLUT4 trafficking, indicating that this area of study has potential for significant advancements in diabetes treatment.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCGRAW, TIMOTHY E — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: MCGRAW, TIMOTHY E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.