How insufficient AMPA receptors affect brain development and function
Impact of Trio Insufficiency on Cholinergic Development and Function
This study is looking at how certain brain receptors, called AMPA receptors, work and how changes in them might affect conditions like drug addiction and autism, so we can better understand these issues and help those who are affected.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10897166 on NIH RePORTER |
What this research studies
This research investigates the role of AMPA receptors in brain function, particularly how their regulation impacts conditions like drug addiction and autism. The study will explore the mechanisms by which auxiliary subunits of AMPA receptors influence their assembly and function, using advanced techniques to track changes in receptor behavior. By examining human variants linked to neurodevelopmental disorders, the research aims to uncover how these variations disrupt normal receptor interactions and affect brain signaling. The findings could lead to a better understanding of the biological underpinnings of addiction and developmental disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with autism spectrum disorder or those affected by drug addiction.
Not a fit: Patients with conditions unrelated to AMPA receptor dysfunction or those not affected by the studied disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating drug addiction and neurodevelopmental disorders.
How similar studies have performed: Previous research has shown promising results in understanding AMPA receptor regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Certain, Noële Doreen — Yale University
- Study coordinator: Certain, Noële Doreen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.