How inositol trisphosphate (IP3) calcium channels control brain cell signaling
Mechanisms of inositol trisphosphate receptor-mediated calcium signaling
This research looks at how tiny calcium channels called IP3 receptors shape signals inside brain cells that are important in Alzheimer's disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11254927 on NIH RePORTER |
What this research studies
This work uses advanced structural imaging and laboratory experiments to observe how IP3 receptors — tiny calcium channels in brain cells — bind molecules and open to release calcium. Scientists will map the receptor’s shape and track how it changes when signals attach, combining high-resolution structure work with functional lab tests on proteins and cells. The team focuses on the neuronal IP3R1 subtype to connect its physical structure to how it controls precise calcium signals that affect cell function and survival. Although this is lab-focused research rather than a clinical treatment effort, it aims to explain how calcium signaling can go wrong in Alzheimer's disease.
Who could benefit from this research
Good fit: People affected by Alzheimer's disease or family members interested in how the disease works would find this research most relevant, though it is primarily laboratory-based.
Not a fit: Patients seeking immediate treatments or clinical interventions are unlikely to benefit directly because this project focuses on basic lab research rather than testing therapies.
Why it matters
Potential benefit: If successful, the findings could point to new molecular targets for therapies that protect brain cells in Alzheimer's disease.
How similar studies have performed: Previous structural and functional studies of calcium channels have clarified how these proteins work, but converting that knowledge into proven Alzheimer's treatments remains early and unproven.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Serysheva, Irina I — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Serysheva, Irina I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.