How inositol pyrophosphates influence cell processes and gene expression
Inositol pyrophosphate dynamics affect RNA 3'-processing/transcription termination
This study is looking at how certain molecules called inositol pyrophosphates (IPPs) affect cell behavior and how changes in these molecules might be linked to health issues like cancer and obesity, with the hope of finding new ways to treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11076357 on NIH RePORTER |
What this research studies
This research investigates the role of inositol pyrophosphates (IPPs), which are important signaling molecules that regulate various cellular functions such as cell growth, migration, and apoptosis. The study focuses on how changes in IPP levels, often due to mutations in enzymes that metabolize these molecules, can lead to diseases like cancer and obesity. By examining the mechanisms of IPP action, particularly in relation to gene expression and cellular responses to phosphate availability, the research aims to uncover fundamental insights into cellular biology that could inform future therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions related to altered cellular signaling, such as cancer, obesity, or diabetes.
Not a fit: Patients with conditions unrelated to cellular signaling or those not affected by inositol pyrophosphate dynamics may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions linked to IPP dysregulation, such as cancer and metabolic disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of signaling molecules in cellular processes, suggesting that this approach may yield valuable insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Schwer, Beate — Weill Medical Coll of Cornell Univ
- Study coordinator: Schwer, Beate
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.