How innate immune cells develop long-lasting memory after vaccination or infection
Unraveling the molecular mechanisms of innate immune memory in humans
Researchers will learn how some vaccines or exposures make immune cells respond faster and stronger in people by studying blood and bone marrow samples.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11326766 on NIH RePORTER |
What this research studies
This project will use single-cell tests to measure gene activity and DNA accessibility in immune cells and bone marrow stem cells before and after exposure to trained-immunity agents such as BCG. The team will include people from diverse ancestry backgrounds to look for genetic and molecular reasons why immune responses differ between individuals. Researchers will trace whether epigenetic changes in stem cells are passed down to the mature immune cells that fight infections. Advanced computational analyses will link the molecular signatures to changes in immune function.
Who could benefit from this research
Good fit: Ideal participants are adults willing to give blood and possibly bone marrow samples, including people vaccinated with BCG or from diverse ancestry groups.
Not a fit: People seeking immediate treatment for an active infection or expecting direct medical benefit from participation should not expect personal clinical improvement from joining this research.
Why it matters
Potential benefit: If successful, this work could guide vaccines or therapies that provide broader and longer-lasting protection against infections.
How similar studies have performed: Earlier human work, including studies of BCG vaccination, has shown trained immunity effects, but mapping the detailed epigenetic mechanisms in human stem cells is still largely new.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Barreiro, Luis Bruno — University of Chicago
- Study coordinator: Barreiro, Luis Bruno
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.