How injury-related histones harm the lining of blood vessels
Molecular Mechanisms of Histone-Induced Endotheliopathy in Trauma
This project tests ways to block damage from histones released during severe injury to protect blood vessels in people with traumatic injuries.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project ID | NIH-11251314 on NIH RePORTER |
What this research studies
If I join, researchers will study how proteins called histones, released into the bloodstream after injury, harm the lining of my blood vessels and affect clotting. They will run lab experiments using blood and tissue models to map the exact molecular steps that cause immediate and longer-term vessel damage. The team will also try new laboratory strategies to protect or rescue the blood-vessel lining after trauma. The ultimate aim is to turn these findings into better tools to diagnose and manage blood-vessel injury after trauma.
Who could benefit from this research
Good fit: Ideal candidates are people who have experienced acute traumatic injury or are willing to donate blood or tissue samples after such injuries.
Not a fit: People without recent traumatic injury or whose vascular problems come from chronic conditions are unlikely to see direct benefits in the near term.
Why it matters
Potential benefit: If successful, this work could lead to new treatments or tests that reduce bleeding and clotting problems after severe injury.
How similar studies have performed: Prior lab studies link extracellular histones to blood-vessel damage, but the detailed molecular pathways and protective strategies proposed here are largely novel and unproven in patients.
Where this research is happening
Burlington, United States
- University of Vermont & St Agric College — Burlington, United States (Active)
Researchers
- Principal investigator: Freeman, Kalev — University of Vermont & St Agric College
- Study coordinator: Freeman, Kalev
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.