How inherited risk for alcohol use disorder affects brain connectivity
Functional connectivity reconfigurations in risk for alcohol use disorders
This study looks at how genes linked to alcohol use disorder affect how different parts of the brain work together, especially when you're thinking or resting, to help us understand the challenges people at risk for alcohol problems might face.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10880662 on NIH RePORTER |
What this research studies
This research investigates how genetic factors related to alcohol use disorder (AUD) influence the brain's functional connectivity, particularly during different mental states. By examining how the brain's networks adapt when transitioning between cognitive tasks and rest, the study aims to uncover the underlying mechanisms of AUD risk. The researchers will analyze brain activity patterns to understand how these changes relate to behaviors associated with alcohol consumption and control. This work could provide insights into the cognitive challenges faced by individuals at risk for AUD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of alcohol use disorders or those who exhibit low executive function and behavioral control.
Not a fit: Patients without any familial or personal history of alcohol use disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and interventions for individuals at risk of developing alcohol use disorders.
How similar studies have performed: Previous research has shown promising results in understanding brain connectivity related to behavioral control, suggesting that this approach may yield valuable insights.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Kareken, David a. — Indiana University Indianapolis
- Study coordinator: Kareken, David a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.