How inherited cancer genes affect tumor behavior and treatment response
Impact of cancer predisposition on oncogenic process, microenvironment, and treatment
This study is looking at how inherited genes might affect the way different cancers grow and respond to treatments, and it's for anyone interested in understanding more about their cancer and how it might be influenced by their family history.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11004023 on NIH RePORTER |
What this research studies
This research investigates the impact of inherited genetic variants on cancer development and treatment outcomes. By analyzing over 10,000 tumors from various cancer types, the study aims to understand how these germline variants differ from somatic mutations in influencing cancer cell characteristics and responses to therapies. The researchers utilize advanced techniques like single-cell RNA sequencing to profile gene expression in both cancerous and non-cancerous cells within the tumor microenvironment. This comprehensive approach seeks to uncover the roles of specific genes, such as BRCA1/2, in tumor progression and treatment efficacy.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of cancer or known germline mutations in cancer predisposition genes.
Not a fit: Patients without any known genetic predispositions or those with cancers unrelated to the genes being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment strategies for cancer patients based on their genetic predispositions.
How similar studies have performed: Previous research has shown promising results in understanding the role of genetic variants in cancer, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Ding, Li — Washington University
- Study coordinator: Ding, Li
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.