How inflammatory monocytes help the body fight Salmonella infections
Role of inflammatory monocytes in immunity and host defense against Salmonella
This study is looking at how a special type of immune cell called inflammatory monocytes helps your body fight off Salmonella infections, which could help us learn more about how our immune system works and improve treatments for infections and other health issues like cancer and sepsis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-10689679 on NIH RePORTER |
What this research studies
This research investigates the role of inflammatory monocytes, a type of immune cell, in the body's defense against Salmonella, a harmful bacteria. The study focuses on how these cells are produced in the bone marrow and how they respond during infections. By examining both the protective and potentially harmful effects of these cells, the research aims to better understand their dual role in immunity. This could lead to new insights into how the body manages bacterial infections and the implications for conditions like cancer and sepsis.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Salmonella infections or those at risk of severe bacterial infections, particularly patients with compromised immune systems.
Not a fit: Patients who do not have bacterial infections or those with stable, non-compromised immune systems may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for infections caused by Salmonella and potentially other bacterial pathogens.
How similar studies have performed: Other research has shown success in understanding the immune response to bacterial infections, making this approach both relevant and promising.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Van Der Velden, Adrianus Wilhelmus Maria — State University New York Stony Brook
- Study coordinator: Van Der Velden, Adrianus Wilhelmus Maria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.