How inflammation in tumor surroundings affects pancreatic cancer growth
Official title: Impact of Inflammatory Pathway in Tumor Stroma on Pancreatic Cancer Growth
Funded at Birmingham VA Medical Center · NIH-11090388 · Data updated 2026-11-12
This study is looking at how certain signals in the supportive tissue around pancreatic cancer cells might help the cancer grow and avoid being attacked by the immune system, with the hope of finding new ways to treat patients with pancreatic cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Birmingham VA Medical Center NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | April 1, 2020 |
| Project end | September 30, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01BX004944-07 |
| Project ID | NIH-11090388 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pancreatic cancer who may benefit from novel treatment approaches targeting the tumor microenvironment.
✕Less likely to help
Patients with non-cancerous conditions or those with pancreatic cancer that has already progressed to an advanced stage may not benefit from this research.
What this research studies
This research investigates the role of inflammatory pathways in the tumor stroma, which is the supportive tissue surrounding cancer cells, in the growth of pancreatic cancer. The study focuses on understanding how NFκB signaling in this stroma may protect cancer cells from being eliminated by the immune system, particularly T cells. By analyzing both laboratory models and human cancer data, the researchers aim to identify key cytokines, like CCL5, that contribute to tumor growth and resistance to treatment. The goal is to uncover new mechanisms that could lead to more effective therapies for pancreatic cancer patients.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve outcomes for pancreatic cancer patients.
How similar studies have gone: Previous research has shown promising results in targeting inflammatory pathways in cancer, suggesting that this approach may yield significant insights and advancements.
Where this research is happening
-
Birmingham VA Medical Center
Birmingham, United States Active
Researchers
- Principal investigator: Dudeja, Vikas — Birmingham VA Medical Center
- Study coordinator: Dudeja, Vikas
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.