How inflammation in the brain affects breathing patterns
Neuroinflammation Maladapts Cardio Respiratory Circuits and Patterns
['FUNDING_R01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-11092309
This study is looking at how inflammation in the brain affects breathing, especially when someone has lung injuries or infections, to find new ways to help people breathe better.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11092309 on ClinicalTrials.gov |
What this research studies
This research investigates how inflammation in the central nervous system impacts the control of breathing, particularly during conditions like lung injury or systemic infections. By studying animal models, the researchers aim to understand how neuro-inflammation alters the respiratory network and affects breathing patterns. They will explore the molecular and functional changes that occur in the brainstem during these inflammatory responses, which could lead to maladaptive breathing behaviors. The findings may help identify new therapeutic targets for improving respiratory function in affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients experiencing acute lung injury or respiratory distress related to systemic infections.
Not a fit: Patients with chronic respiratory conditions unrelated to inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve breathing in patients suffering from respiratory complications due to inflammation.
How similar studies have performed: Previous research has shown that targeting neuro-inflammation can lead to improvements in respiratory function, suggesting that this approach may be promising.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JACONO, FRANK JOSEPH — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: JACONO, FRANK JOSEPH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acute Lung Injury, Acute Pulmonary Injury, acute respiratory distress syndrome caused by sepsis