How inflammation from asthma may influence Alzheimer's disease development
Official title: Investigating the mechanisms by which systemic inflammation promotes Alzheimer’s disease: Asthma as a model and modifiable risk factor
Funded at University of Wisconsin-Madison · NIH-10661382 · Data updated 2026-11-12
This study is looking at how inflammation from asthma might be linked to Alzheimer's disease, with the hope of finding ways to slow down or prevent memory loss for people who have asthma.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $2,261,120 |
| NIH project number | 1RF1AG082215-01 |
| Project ID | NIH-10661382 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with asthma who are at risk for developing Alzheimer's disease.
✕Less likely to help
Patients without asthma or those who do not have any risk factors for Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the connection between systemic inflammation, particularly from asthma, and the development of Alzheimer's disease. By studying the inflammatory pathways that may accelerate Alzheimer's, the project aims to identify potential intervention targets that could help delay or prevent cognitive decline. The research utilizes advanced imaging techniques, such as positron emission tomography (PET), to observe changes in the brain associated with inflammation and Alzheimer's pathology. The goal is to better understand how chronic inflammatory conditions like asthma can impact brain health over time.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or delaying Alzheimer's disease in individuals with chronic inflammatory conditions.
How similar studies have gone: Previous research has indicated that targeting inflammatory pathways may hold promise for reducing dementia risk, suggesting that this approach could be beneficial.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Rosenkranz, Melissa a — University of Wisconsin-Madison
- Study coordinator: Rosenkranz, Melissa a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.