How inflammation changes JAK2-mutated blood stem cells
Effect of inflammation on JAK2 mutant evolution in the hematopoietic system: mathematical models and experiments
This project looks at how inflammation alters the growth of JAK2-mutated blood stem cells in people with early myeloproliferative neoplasms (MPN).
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11306685 on NIH RePORTER |
What this research studies
You should know that this work combines computer-based mathematical models with lab experiments to understand how inflammation influences JAK2V617F mutant blood stem cells. The team will use cell and experimental models to measure how mutant and normal cells grow under inflammatory conditions and will compare those results to predictions from their models. Their goal is to identify signals or strategies that could change the evolutionary advantage of the mutant cells and slow disease progression. Findings could point to ways to intervene earlier in MPN to reduce the risk of worsening disease.
Who could benefit from this research
Good fit: Ideal candidates would be people with early-stage MPN who carry the JAK2V617F mutation or have a documented JAK2 mutation and are willing to provide clinical information or samples.
Not a fit: Patients with advanced myelofibrosis or secondary acute leukemia, or those whose disease does not involve JAK2 mutations, are less likely to benefit directly from this work.
Why it matters
Potential benefit: If successful, this research could lead to approaches that slow or stop progression from early MPN to myelofibrosis or acute leukemia.
How similar studies have performed: Prior laboratory and modeling work by the investigators suggests inflammation can speed JAK2-mutant cell growth, but translating that insight into patient-targeted therapies remains largely untested.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Fleischman, Angela Goffredo — University of California-Irvine
- Study coordinator: Fleischman, Angela Goffredo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.