How inflammation changes blood stem cells and drives progression in chronic myelomonocytic leukemia
The impact of inflammation on HSPC composition and disease progression in chronic myelomonocytic leukemia
['FUNDING_R01'] · H. LEE MOFFITT CANCER CTR & RES INST · NIH-11285307
Looking at whether inflammation changes blood stem cells and speeds disease in adults with CMML.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | H. LEE MOFFITT CANCER CTR & RES INST (nih funded) |
| Locations | 1 site (TAMPA, UNITED STATES) |
| Trial ID | NIH-11285307 on ClinicalTrials.gov |
What this research studies
As someone with CMML, this project will examine how inflammation alters the mix of blood stem and progenitor cells in your bone marrow and blood. Researchers will analyze patient blood and bone marrow samples over time and compare molecular patterns in people who progress to AML versus those who remain stable. They will also use laboratory models that mimic inflammation to see if inflammatory programs make certain leukemia stem cells more competitive. Findings will be linked to clinical outcomes to help identify markers or targets to slow progression.
Who could benefit from this research
Good fit: Adults diagnosed with CMML who can provide blood and/or bone marrow samples and agree to clinical follow-up are the ideal candidates.
Not a fit: People without CMML, those already in frank AML, or individuals unwilling to give samples or attend follow-up visits are unlikely to benefit directly.
Why it matters
Potential benefit: If successful, this could identify inflammatory markers or pathways that predict or slow CMML progression and reduce the chance of transformation to AML.
How similar studies have performed: Preliminary lab work and a retrospective patient cohort suggest inflammatory shifts in progenitor cells are linked to worse outcomes, but translating this into clinical markers and therapies is still new.
Where this research is happening
TAMPA, UNITED STATES
- H. LEE MOFFITT CANCER CTR & RES INST — TAMPA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PADRON, ERIC — H. LEE MOFFITT CANCER CTR & RES INST
- Study coordinator: PADRON, ERIC
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.