How inflammation and swelling reshape body tissues
Computational Biomechanics Modeling of Inflammation
['FUNDING_OTHER'] · UNIVERSITY OF NOTRE DAME · NIH-11196733
This project builds computer models to help understand how inflammation and swelling change tissues in people with inflammatory conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NOTRE DAME (nih funded) |
| Locations | 1 site (NOTRE DAME, UNITED STATES) |
| Trial ID | NIH-11196733 on ClinicalTrials.gov |
What this research studies
If you have an inflammatory condition, this team uses computer simulations and mathematical models to show how cells and tissues swell, pressurize, and change shape over time. The work combines mechanical laws (like pressure and force) with biological details so cell behavior can vary by location, time, and cell type. The models will capture both visible swelling and hidden pressure increases that can occur when surrounding tissues constrain expansion. Researchers at the CoMMaND Lab at the University of Notre Dame will develop and refine these models to improve predictions of tissue responses during inflammation.
Who could benefit from this research
Good fit: People with diseases that involve tissue inflammation and swelling—for example inflammatory arthritis, localized edema, or organ inflammation—would be the most relevant group who could benefit from this work.
Not a fit: People with health problems that are not driven by tissue inflammation or mechanical tissue changes are unlikely to benefit directly from this modeling work.
Why it matters
Potential benefit: If successful, these models could help clinicians detect hidden tissue pressure, predict disease progression, and target treatments more precisely for inflammatory conditions.
How similar studies have performed: Biomechanical and growth-remodeling models have informed understanding in other contexts, but applying coupled mechanical–cellular models specifically to inflammation and swelling is a newer and less-tested approach.
Where this research is happening
NOTRE DAME, UNITED STATES
- UNIVERSITY OF NOTRE DAME — NOTRE DAME, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HOLLAND, MARIA — UNIVERSITY OF NOTRE DAME
- Study coordinator: HOLLAND, MARIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.